Can you make out from the context of the story or situation the meaning? Take a guess!
If you guessed that this phrase means "to start over again," that's correct!
This phrase is often used when original plans or ideas are identified and don't work out and we have to start all over again. Based on their tone of voice, they could be positive about the situation or frustrated. To hear the definition of this idiom by Andrea of ESL basics, watch the video below.